Hydraulic fracturing is a well completion technique for Oil and Gas production enhancement in both conventional and unconventional reservoirs. However, it can result in the unfavorable consequence of the premature screen-out, which occurs due to the proppant bridging across the perforations or similar restricted flow areas.The objective of this work is to propose a novel framework of analysis that enables to quantify the risk of screen-out occurrence, to identify the riskiest scenarios and to determine the best risk mitigation strategies. The premature screen-out problem is addressed within a Risk Management and Control Process, wherein the qualitative and quantitative assessments of the early screen-out risk are performed by a Features, Events and Processes Analysis structured with a Bayesian Belief Network. The BBN probabilities are subject to a thorough uncertainty and sensitivity analysis. Sensitivity analysis is performed by the Sobol's variance decomposition method and the identified most influential probabilities of the BBN are re-estimated in order to reduce the output uncertainty.Finally, risk mitigation plans are formulated using risk importance measures to identify the riskiest scenarios and cost-benefit analysis to determine the optimal risk reduction actionsThe developed framework has been applied to a case study of vertical wells.