This study aims to highlight the interactions between an inducer and an impeller, two key components of a centrifugal pump. Two configurations are studied: inducer alone and inducer and impeller. Low flow-rates (3% ϕn, 30% ϕn, 60% ϕn) and low-pressure conditions, for which cavitation occurs, are investigated. The hydromechanical performance is studied and compared for both configurations, and cavitation formation is depicted using a high-speed camera. It has been shown that two types of cavitation occur: tip vortex cavitation and cavitation induced by inlet prerotation. Both types are dependent on inlet pressure and flow rate. The former does not significantly impact the head pressure coefficient, whereas the latter grows as the inlet pressure decreases and eventually causes the pump stall when reaching the blades. Furthermore, inlet pre-rotation is exacerbated by the presence of the impeller, deteriorating the overall pump performance. Despite the inducer’s stall, the pump is still capable of pressurizing the fluid, and the impeller seems to compensate a percentage of the pressure drop by increasing its own contribution.