Electrical Sensing of sickled red blood cells subpopulations in microfluidic device

This paper discusses the electrical sensing of red blood cell (RBC) rigidity due to Hemoglobin S (HbS) polymerization in sickle cell disease. For this purpose sickle RBCs subpopulations, differentiated by cell density, were flown through a microfluidic device equipped with integrated microelectrodes. Differences in transit time and electrical blockade were observed and analyzed.

Mots clés

Sickle Cell Disease Electrical Sensing Microfluidic

Domaines

Micro et nanotechnologies/Microélectronique Sciences du Vivant [q-bio]

Fichier principal

MicroTAS_2020_XU.pdf (409.01 Ko)

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Bruno Le Pioufle : Connectez-vous pour contacter le contributeur

https://hal.science/hal-03078878

Soumis le : lundi 4 janvier 2021-17:43:22

Dernière modification le : vendredi 19 juillet 2024-11:38:05

Archivage à long terme le : lundi 5 avril 2021-18:39:57

Dates et versions

hal-03078878 , version 1 (04-01-2021)

Identifiants

HAL Id : hal-03078878 , version 1

Citer

Tieying Xu, Maria A Lizarralde-Iragorri, Jean Roman, Emile Martincic, Valentine Brousse, et al.. Electrical Sensing of sickled red blood cells subpopulations in microfluidic device. MicroTAS, Oct 2020, on-line, France. ⟨hal-03078878⟩

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