Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 - Cnam - Conservatoire national des arts et métiers
Article Dans Une Revue Journal of Infectious Diseases Année : 2021

Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2

Isabelle Staropoli
Hugo Mouquet
Nathalie Reix
Yves Hansmann
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Timothée Bruel

Résumé

We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged >50 years and participants with a body mass index (BMI) >25 kg/m2. At months 3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response.
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Dates et versions

hal-03606632 , version 1 (11-03-2022)

Identifiants

Citer

Ludivine Grzelak, Auréie Velay-Rusch, Yoann Madec, Floriane Gallais, Isabelle Staropoli, et al.. Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2. Journal of Infectious Diseases, 2021, 224 (6), pp.983-988. ⟨10.1093/infdis/jiab127⟩. ⟨hal-03606632⟩
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