The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control - Cnam - Conservatoire national des arts et métiers Accéder directement au contenu
Article Dans Une Revue Frontiers in Immunology Année : 2023

The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control

Résumé

Discussion: These findings suggest that additional molecular mechanisms beyond the conventional antigen-presenting role of class I HLA molecules may contribute to the observed influence of HLA-B*57:01/B*57:03 alleles on HIV-1 elite control. Overall, this study has uncovered a large haploblock associated with HLA-B*57 alleles, providing novel insights into their massive effect on HIV-1 elite control.
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Dates et versions

hal-04351478 , version 1 (18-12-2023)

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Myriam Rahmouni, Lorenzo de Marco, Jean-Louis Spadoni, Maxime Tison, Raissa Medina-Santos, et al.. The HLA-B*57:01 allele corresponds to a very large MHC haploblock likely explaining its massive effect for HIV-1 elite control. Frontiers in Immunology, 2023, 14, ⟨10.3389/fimmu.2023.1305856⟩. ⟨hal-04351478⟩
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