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Article Dans Une Revue Molecules Année : 2020

Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras

Résumé

Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.
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Dates et versions

mnhn-02867368 , version 1 (15-07-2024)

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Tapé Kouamé, Aboua Timothée Okpekon, Nicaise Bony, Amon Diane N’tamon, Jean-François Gallard, et al.. Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras. Molecules, 2020, 25 (11), pp.2654. ⟨10.3390/molecules25112654⟩. ⟨mnhn-02867368⟩
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