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Article Dans Une Revue Matrix Biology Année : 2024

Tenascin-C targeting strategies in cancer

Résumé

Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.
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hal-04608013 , version 1 (11-06-2024)

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Sayda Dhaouadi, Balkiss Bouhaouala-Zahar, Gertraud Orend. Tenascin-C targeting strategies in cancer. Matrix Biology, 2024, 130, pp.1-19. ⟨10.1016/j.matbio.2024.04.002⟩. ⟨hal-04608013⟩
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