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Journal Articles Journal of Cystic Fibrosis Year : 2017

A 3-year prognostic score for adults with cystic fibrosis

Abstract

Background: Therapeutic progress in patients with cystic fibrosis (CF) has resulted in improved prognosis over the past decades. We aim to reevaluate prognostic factors of CF and provide a prognostic score to predict the risk of death or lung transplantation (LT) within a 3-year period in adult patients. Methods: We developed a logistic model using data from the French CF Registry and combined the coefficients into a prognostic score. The discriminative abilities of the model and the prognostic score were assessed by c-statistic. The prognostic score was validated using a 10-fold cross validation. Results: The risk of death or LT within 3 years was related to eight characteristics. The development and the validation provided excellent results for the prognostic score; the c-statistic was 0.91 and 0.90 respectively. Conclusion: The score developed to predict 3-year death or LT in adults with CF might be useful for clinicians to identify patients requiring specialized evaluation for LT.
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Licence : CC BY NC ND - Attribution - NonCommercial - NoDerivatives
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Dates and versions

hal-02080563 , version 1 (26-03-2019)

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Lionelle Nkam, J. Lambert, Aurélien Latouche, Gil Bellis, P.-R. Burgel, et al.. A 3-year prognostic score for adults with cystic fibrosis. Journal of Cystic Fibrosis, 2017, 16 (6), pp.702-708. ⟨10.1016/j.jcf.2017.03.004⟩. ⟨hal-02080563⟩
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